Canki N
Jugosl Ginekol Opstet. 1984 May-Aug;24(3-4):45-8.
The analysis of thirty-seven cases of neural tube defects (NTD) resulted in the following conclusions: a) At least eleven cases had the Arnold-Chiari malformation, an autosomal recessive disorder which often remains unrecognized; b) Trisomy 18 and amniotic disease associated with NTD were diagnosed in two newborns; c) In eight cases there was one or more older children with NTD; d) In two families the parents were related. A review of the literature and the exposed data indicate a heterogeneous etiology and an important role of genetic factors in the genesis of NTD.
对37例神经管缺陷（NTD）病例的分析得出以下结论：a）至少11例患有阿诺德 - 基亚里畸形，这是一种常未被识别的常染色体隐性疾病；b）两名新生儿被诊断出18三体综合征和与NTD相关的羊水疾病；c）8例中有一个或多个患有NTD的大龄儿童；d）两个家庭的父母有亲属关系。对文献和所呈现数据的回顾表明，NTD发生的病因具有异质性，且遗传因素起重要作用。
