Chisholm D J, Kraegen E W, Bell D J, Chipps D R
Med J Aust. 1984;141(12-13):784-9.
Closed loop insulin delivery systems are impractical for widespread hospital use. Thus, a semi-closed loop computer-assisted insulin infusion system (CAIIS) was developed for the intravenous delivery of insulin. In its basal program, insulin delivery is determined by blood glucose measurements at intervals of three hours, while the open-loop meal program delivers 7.5 units over three hours. Control of meal-induced hyperglycaemia was satisfactory in six subjects with diabetes tested over two to four days, as was mean glycaemic control in the four non-obese subjects (7.1 +/- 0.8 mmol/L). To allow for variations in insulin sensitivity, an adjustment incrementing or decrementing the basal insulin delivery rate was applied according to the progressive blood glucose response. Empirical use of this adjustment resulted in good control (mean blood glucose level, 4.1-7.5 mmol/L) in 10 additional subjects with diabetes. This study demonstrates the potential usefulness of a semi-closed loop insulin infusion system.
闭环胰岛素输送系统在医院广泛应用中并不实用。因此，开发了一种半闭环计算机辅助胰岛素输注系统（CAIIS）用于静脉输注胰岛素。在其基础程序中，胰岛素输送由每三小时一次的血糖测量值决定，而开环进餐程序在三小时内输送7.5单位胰岛素。在两到四天内对六名糖尿病患者进行测试，进餐诱发的高血糖控制令人满意，四名非肥胖受试者的平均血糖控制情况也是如此（7.1±0.8毫摩尔/升）。为了适应胰岛素敏感性的变化，根据逐步的血糖反应应用了调整基础胰岛素输送速率的增量或减量。对另外十名糖尿病患者进行经验性使用这种调整后，实现了良好的控制（平均血糖水平为4.至7.5毫摩尔/升）。这项研究证明了半闭环胰岛素输注系统的潜在实用性。
