Strack T, Krause U, Schulz G, Beyer J, Beutelspacher F, Nagel J
Horm Metab Res. 1984 Apr;16(4):163-7. doi: 10.1055/s-2007-1014733.
A computer controlled syringe-type insulin infusion pump storing up to 254 different infusion rates, eight different meal programs and two different basal rates automatically changeable during 24 h in EPROM was used for insulin infusion applying a wavy step profile. This profile approaching the physiological postprandial insulin secretion of the B-cell was calculated by an algorithm following the biphasic insulin secretion model proposed by E. Cerasi . The computer program for the open loop infusion device simulated the feed-back structure of a closed loop insulin secretion control by an algorithm based upon a theoretical postprandial blood sugar profile. Fifteen unstable juvenile onset insulin requiring diabetics could be well controlled after two to three days of an intravenous open loop insulin infusion program. The programs consisted of two constant basal rates and superimposed wavy step profile programs activated at the beginning of each meal. The preabsorptive bolus or cephalic phase was an additional tool both for improved postprandial blood sugar control and further reduction of insulin consumption. The programmable insulin infusion device proved as a valuable tool for the study of a sophisticated insulin infusion profile suitable as well for open loop as for closed loop insulin infusion systems.
使用了一种计算机控制的注射器式胰岛素输注泵，该泵在EPROM中可存储多达254种不同的输注速率、8种不同的进餐程序和2种在24小时内可自动变化的基础速率，用于采用波浪阶梯式曲线进行胰岛素输注。这种接近B细胞生理性餐后胰岛素分泌的曲线是根据E. Cerasi提出的双相胰岛素分泌模型，通过一种算法计算得出的。开环输注装置的计算机程序通过基于理论餐后血糖曲线的算法模拟闭环胰岛素分泌控制的反馈结构。15名需要胰岛素治疗的不稳定青少年糖尿病患者在进行两到三天的静脉开环胰岛素输注程序后，血糖得到了良好控制。这些程序包括两种恒定的基础速率以及在每餐开始时启动的叠加波浪阶梯式曲线程序。吸收前推注或头期是改善餐后血糖控制和进一步减少胰岛素消耗的额外手段。可编程胰岛素输注装置被证明是研究复杂胰岛素输注曲线的有价值工具，适用于开环和闭环胰岛素输注系统。
