Yates R W, Weller R E, Feldman B F
Mod Vet Pract. 1984 Oct;65(10):753-7.
Myeloproliferative disorders, a complex of cytologic abnormalities arising in the bone marrow, are among domestic animals most frequently recognized in cats but are relatively uncommon. A 4-year-old female Siamese, with splenomegaly and weight loss, was listless, anorectic, pale and dehydrated. A hemogram showed severe, macrocytic normochromic anemia, leukocytosis and reticulocytosis, with abnormally high numbers of nucleated RBC and undifferentiated blast cells. Bone marrow smears contained predominantly undifferentiated blast cells, RBC precursors and myeloblasts. The fluorescent antibody test for FeLV was positive. The cat died 66 days later despite a blood transfusion and chemotherapy. Necropsy confirmed a diagnosis of myeloproliferative disease, with hepatic and splenic invasion.
骨髓增殖性疾病是一种发生于骨髓的细胞异常综合征，在家畜中较为常见，其中猫最为多发，但相对少见。一只4岁雌性暹罗猫，出现脾肿大和体重减轻，精神萎靡、食欲不振、面色苍白且脱水。血常规显示严重的大细胞正色素性贫血、白细胞增多和网织红细胞增多，有核红细胞和未分化母细胞数量异常高。骨髓涂片主要包含未分化母细胞、红细胞前体和成髓细胞。猫白血病病毒（FeLV）荧光抗体检测呈阳性。尽管进行了输血和化疗，这只猫在66天后死亡。尸检确诊为骨髓增殖性疾病，并伴有肝脏和脾脏浸润。
