Krivtsova M A, Moroshkina E B, Glibin E N, Frisman E V
Mol Biol (Mosk). 1984 Jul-Aug;18(4):950-6.
The DNA complexes with distactins have been investigated by means of spectrophotometry, viscosimetry and flow birefringence methods. The distactins are actinocin's derivatives containing in the 1,9 positions of the phenoxazone moiety oligopyrrolcarboxamide groups (like those of distamycin A), which have from one to three fragments of 1-methyl-4-amino-2-pyrrolic acid. The mode of DNA-distactins binding in water solution depends on the quantity of the methylpyrrole rings in the oligopeptide groups. The ligand with oligopeptide groups containing three methylpyrrole rings joins the DNA double helix only from outside by means of oligopeptide groups. The compounds with one and two methylpyrrole rings form two kinds of complexes with DNA: external binding and intercalation. In the latter case both chromophore and methylpyrrole fragments, interact with DNA.
已通过分光光度法、粘度测定法和流动双折射法对与远霉素形成的DNA复合物进行了研究。远霉素是放线菌素的衍生物，在吩恶嗪部分的1,9位含有寡聚吡咯甲酰胺基团（类似于偏端霉素A），其具有一至三个1-甲基-4-氨基-2-吡咯酸片段。水溶液中DNA与远霉素的结合方式取决于寡肽基团中甲基吡咯环的数量。含有三个甲基吡咯环的寡肽基团配体仅通过寡肽基团从外部与DNA双螺旋结合。含有一个和两个甲基吡咯环的化合物与DNA形成两种复合物：外部结合和嵌入。在后一种情况下，发色团和甲基吡咯片段均与DNA相互作用。
