Mitchison T, Kirschner M
Nature. 1984;312(5991):232-7. doi: 10.1038/312232a0.
Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.
微管参与大多数细胞的形态发生,是有丝分裂纺锤体的结构基础。我们在此报告,纯化的中心体可促使具有异常动态特性的微管组装。这可能对细胞中微管阵列的组织和稳定机制具有重要意义。