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[克林霉素和交沙霉素对实验性弓形虫感染的影响]

[Effects of clindamycin and josamycin in experimental Toxoplasma gondii infections].

作者信息

Terragna A, Canessa A, Terragna F M, Corradino L

出版信息

Minerva Med. 1984 Oct 13;75(39):2305-8.

PMID:6504394
Abstract

The effects of clindamycin and josamycin on experimental toxoplasmosis of mice (RH strain) are studied. Oral administration of clindamycin 800 mg/kg daily for 14 days cured 80% of Toxoplasma-infected mice at 60 days after infection. Josamycin, administered subcutaneously at 100, 200, 500, 1000 mg/kg daily for 14 days did not prevent death due to acute infection, and no difference was demonstrated with untreated infected mice.

摘要

研究了克林霉素和交沙霉素对小鼠(RH株)实验性弓形虫病的影响。每天口服800mg/kg克林霉素,连续14天,感染弓形虫的小鼠在感染后60天有80%被治愈。每天皮下注射100、200、500、1000mg/kg交沙霉素,连续14天,未能预防急性感染导致的死亡,且与未治疗的感染小鼠相比无差异。

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