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胸苷酰-3',5'-胸苷中是否有时存在T-T摆动配对?

Is there sometimes T-T wobble pairing in thymidylyl-3',5'-thymidine?

作者信息

Tollin P, Walker R T, Wilson H R

出版信息

Nucleic Acids Res. 1984 Nov 26;12(22):8345-7. doi: 10.1093/nar/12.22.8345.

Abstract

A fibre-type x-ray diffraction photograph from thymidylyl-3',5'-thymidine is interpreted in terms of a seven-residues per turn, left-handed helical structure in which the first thymine of one molecule is linked to the second thymine of the next molecule by 'wobble' type hydrogen bonds. The first thymidine is in the anti conformation, with a C2'endo - C3'exo sugar and the second is in the syn conformation with a C3'endo - C4'exo sugar. The C5' - 05' bond in the inter-nucleotide linkage is in the g- conformation and that of the P-05' is g+.

摘要

来自胸苷-3',5'-胸苷的纤维型X射线衍射照片被解释为具有每圈七个残基的左手螺旋结构,其中一个分子的第一个胸腺嘧啶通过“摆动”型氢键与下一个分子的第二个胸腺嘧啶相连。第一个胸苷处于反式构象,具有C2'内 - C3'外的糖,第二个处于顺式构象,具有C3'内 - C4'外的糖。核苷酸间连接中的C5'-O5'键处于g-构象,而P-O5'键处于g+构象。

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