• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

胸苷酰-3',5'-胸苷中是否有时存在T-T摆动配对?

Is there sometimes T-T wobble pairing in thymidylyl-3',5'-thymidine?

作者信息

Tollin P, Walker R T, Wilson H R

出版信息

Nucleic Acids Res. 1984 Nov 26;12(22):8345-7. doi: 10.1093/nar/12.22.8345.

DOI:10.1093/nar/12.22.8345
PMID:6504701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320366/
Abstract

A fibre-type x-ray diffraction photograph from thymidylyl-3',5'-thymidine is interpreted in terms of a seven-residues per turn, left-handed helical structure in which the first thymine of one molecule is linked to the second thymine of the next molecule by 'wobble' type hydrogen bonds. The first thymidine is in the anti conformation, with a C2'endo - C3'exo sugar and the second is in the syn conformation with a C3'endo - C4'exo sugar. The C5' - 05' bond in the inter-nucleotide linkage is in the g- conformation and that of the P-05' is g+.

摘要

来自胸苷-3',5'-胸苷的纤维型X射线衍射照片被解释为具有每圈七个残基的左手螺旋结构,其中一个分子的第一个胸腺嘧啶通过“摆动”型氢键与下一个分子的第二个胸腺嘧啶相连。第一个胸苷处于反式构象,具有C2'内 - C3'外的糖,第二个处于顺式构象,具有C3'内 - C4'外的糖。核苷酸间连接中的C5'-O5'键处于g-构象,而P-O5'键处于g+构象。

相似文献

1
Is there sometimes T-T wobble pairing in thymidylyl-3',5'-thymidine?胸苷酰-3',5'-胸苷中是否有时存在T-T摆动配对?
Nucleic Acids Res. 1984 Nov 26;12(22):8345-7. doi: 10.1093/nar/12.22.8345.
2
The occurence of the syn-C3' endo conformation and the distorted backbone conformations for C4'-C5' and P-O5' in oligo and polynucleotides.寡核苷酸和多核苷酸中C3' 内型构象的出现以及C4'-C5' 和P-O5' 的扭曲主链构象。
J Biomol Struct Dyn. 2001 Jun;18(6):824-31. doi: 10.1080/07391102.2001.10506710.
3
Nuclear magnetic resonance studies of cis-syn, trans-syn, and 6-4 photodimers of thymidylyl(3'-5')thymidine monophosphate and cis-syn photodimers of thymidylyl(3'-5')thymidine cyanoethyl phosphotriester.胸苷酸(3'-5')胸苷单磷酸的顺式-顺式、反式-顺式和6-4光二聚体以及胸苷酸(3'-5')胸苷氰乙基磷酸三酯的顺式-顺式光二聚体的核磁共振研究。
Biochemistry. 1988 Jul 26;27(15):5796-803. doi: 10.1021/bi00415a060.
4
The nature of conformational correlations in alpha- and beta-anomers of nucleic acid components in aqueous solution by nuclear magnetic resonance.
J Biomol Struct Dyn. 1988 Oct;6(2):367-82. doi: 10.1080/07391102.1988.10507719.
5
Local and overall conformations of DNA double helices with the A - T base pairs.具有A - T碱基对的DNA双螺旋的局部和整体构象。
Biochim Biophys Acta. 1986 Aug 22;867(4):256-67. doi: 10.1016/0167-4781(86)90042-4.
6
Two-dimensional 1H NMR study of two cyclobutane type photodimers of thymidylyl-(3'----5')-thymidine.胸苷酰基-(3'→5')-胸苷的两种环丁烷型光二聚体的二维¹H核磁共振研究
Eur Biophys J. 1987;14(5):293-9. doi: 10.1007/BF00254894.
7
Stereochemistry of 2'-5' linked nucleic acids: crystal and molecular structure of ammonium adenylyl-2',5'-adenosine tetrahydrate: a core fragment of 2'-5' oligo A's produced by interferon induced adenylate synthetase.2'-5'连接核酸的立体化学:腺苷酰-2',5'-腺苷铵四水合物的晶体和分子结构:干扰素诱导的腺苷酸合成酶产生的2'-5'寡聚A的核心片段
J Biomol Struct Dyn. 1993 Feb;10(4):727-45. doi: 10.1080/07391102.1993.10508003.
8
Crystal structure of the cis-syn photodimer of thymidylyl (3'-5') thymidine cyanoethyl ester.胸苷酰(3'-5')胸苷氰基乙酯顺式-顺式光二聚体的晶体结构。
Biopolymers. 1985 May;24(5):897-903. doi: 10.1002/bip.360240512.
9
A comparative conformational study of thymidylyl(3'----5')-thymidine, thymidylyl(3'----5')-5'-thio-5'- deoxythymidine and thymidinylacetamido-[3'(O)----5'(C)]-5'-deoxythymidine.胸苷酰(3'→5')-胸苷、胸苷酰(3'→5')-5'-硫代-5'-脱氧胸苷及胸苷乙酰氨基-[3'(O)→5'(C)]-5'-脱氧胸苷的构象比较研究
J Biochem Biophys Methods. 1990 Nov-Dec;21(4):311-32. doi: 10.1016/0165-022x(90)90006-x.
10
NMR structure of a 2',5' RNA favors A type duplex with compact C2'endo nucleotide repeat.2',5' RNA的核磁共振结构倾向于具有紧密C2'内型核苷酸重复序列的A型双链体。
Biochem Biophys Res Commun. 2001 May 11;283(3):537-43. doi: 10.1006/bbrc.2001.4828.

本文引用的文献

1
Proton NMR study and conformational analysis of d(CGT), d(TCG) and d(CGTCG) in aqueous solution. The effect of a dangling thymidine and of a thymidine mismatch on DNA mini-duplexes.水溶液中d(CGT)、d(TCG)和d(CGTCG)的质子核磁共振研究与构象分析。游离胸苷和胸苷错配对DNA小双链体的影响。
Nucleic Acids Res. 1984 Jun 25;12(12):5061-78. doi: 10.1093/nar/12.12.5061.
2
Codon--anticodon pairing: the wobble hypothesis.密码子-反密码子配对:摆动假说
J Mol Biol. 1966 Aug;19(2):548-55. doi: 10.1016/s0022-2836(66)80022-0.
3
A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate.
一种处于顺式构象的嘧啶核苷:4-硫代尿苷水合物的分子结构和晶体结构
J Mol Biol. 1970 May 28;50(1):153-69. doi: 10.1016/0022-2836(70)90112-9.
4
Double helix formed by the dinucleoside phosphate thymidylyl-3',5'-deoxyadenosine.由磷酸二核苷胸苷酰-3',5'-脱氧腺苷形成的双螺旋结构。
Nature. 1974 Oct 25;251(5477):735-6. doi: 10.1038/251735a0.
5
X-ray structure of 3',5'-diacetyl-2'-deoxy-2'-fluorouridine: a pyrimidine nucleoside in the syn conformation.3',5'-二乙酰基-2'-脱氧-2'-氟尿苷的X射线结构:一种处于顺式构象的嘧啶核苷。
Biochim Biophys Acta. 1974 Sep 13;361(3):257-65. doi: 10.1016/0005-2787(74)90369-4.
6
Structure of thymidylyl-3',5'-deoxyadenosine.胸苷酰-3',5'-脱氧腺苷的结构
Nature. 1976 Sep 9;263(5573):171-2. doi: 10.1038/263171a0.
7
Local destabilisation of a DNA double helix by a T--T wobble pair.T-T摆动配对导致DNA双螺旋局部不稳定。
Nature. 1979 Sep 20;281(5728):235-6. doi: 10.1038/281235a0.
8
On the physical basis for ambiguity in genetic coding interactions.关于遗传编码相互作用中模糊性的物理基础。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):610-4. doi: 10.1073/pnas.75.2.610.