Rudolph R H
Postgrad Med. 1984 Nov 15;76(7):155-60, 163. doi: 10.1080/00325481.1984.11698807.
Early detection of breast cancer provides the best chance of cure. For women with stage O or clinical stage I disease, two surgical options are available, with equivalent long-term survival. An increasing number of these women are choosing lumpectomy with radiation therapy to the remaining breast tissue rather than modified radical mastectomy. Clinical stage II patients are treated with modified radical mastectomy. For premenopausal women with positive axillary lymph nodes, six months of adjuvant chemotherapy increases survival. Whether postmenopausal women with positive nodes benefit from chemotherapy is unclear. At present they are best treated in the context of a therapeutic trial. A subset of premenopausal women with stage I breast cancer have tumors that are estrogen receptor-negative and are at high risk of recurrence. These women may benefit from adjuvant chemotherapy and should be entered into a therapeutic trial.
早期发现乳腺癌可提供最佳的治愈机会。对于0期或临床I期疾病的女性，有两种手术选择，长期生存率相当。越来越多的此类女性选择对剩余乳腺组织进行放疗的保乳手术，而非改良根治性乳房切除术。临床II期患者接受改良根治性乳房切除术治疗。对于腋窝淋巴结阳性的绝经前女性，六个月的辅助化疗可提高生存率。淋巴结阳性的绝经后女性是否从化疗中获益尚不清楚。目前，她们最好在治疗试验的背景下接受治疗。一部分I期乳腺癌的绝经前女性肿瘤雌激素受体阴性，复发风险高。这些女性可能从辅助化疗中获益，应纳入治疗试验。
