Skinner J L, Venables T L, Sheldon M G
Pharmatherapeutica. 1984;4(1):25-31.
In a multi-centre study in general practice, 292 female patients with acute urinary tract infection received a 5-day course of pivmecillinam at a dosage of either 200 mg or 400 mg twice-daily. Positive bacteriological cultures were obtained from 64 (31%) of 206 patients for whom bacteriological data was complete, and bacteriological cures were obtained in all 38 patients in the lower dose group and 22 (85%) of the 26 patients in the higher dose group. An equally good clinical response was seen with both treatments and the mean symptom score (maximum possible 15) was reduced from 7.46 to 0.73. Side-effects were reported for 7 (4%) patients in the lower dose group and 11 (10%) patients in the higher dose group. Two patients in each group ceased treatment due to nausea, which was the most frequently reported complaint.
在一项全科医疗的多中心研究中，292名急性尿路感染的女性患者接受了为期5天的匹美西林治疗，剂量为每日两次，每次200毫克或400毫克。在206名有完整细菌学数据的患者中，64名（31%）获得了阳性细菌培养结果，低剂量组的38名患者和高剂量组的26名患者中的22名（85%）获得了细菌学治愈。两种治疗方法都有同样良好的临床反应，平均症状评分（最高可能为15分）从7.46降至0.73。低剂量组有7名（4%）患者报告了副作用，高剂量组有11名（10%）患者报告了副作用。每组有两名患者因恶心而停止治疗，恶心是最常报告的不适。
