Richards H H
Curr Med Res Opin. 1984;9(3):197-203. doi: 10.1185/03007998409109580.
In a multi-centre general practice study, 183 females suffering from symptoms of acute urinary tract infection were randomly assigned to receive 400 mg pivmecillinam twice-daily for either 3 or 7 days. The clinical response was equally good in both treatment groups with a mean reduction in symptom scores of 88%. Positive pre-treatment bacteriological cultures were obtained from 48 (36%) of the 134 patients for whom data were complete. Bacteriological cure was achieved in all these patients except for 1 in the 3-day treatment group. Pivmecillinam was well tolerated, with side-effects reported by 7 (7%) patients in the 3-day group and 12 (13%) patients in the 7-day group. One patient in the 3-day group and 2 patients in the 7-day group stopped treatment prematurely due to side-effects.
在一项多中心全科医疗研究中，183名有急性尿路感染症状的女性被随机分配，接受每日两次、每次400毫克匹美西林，疗程为3天或7天。两个治疗组的临床反应同样良好，症状评分平均降低了88%。在数据完整的134名患者中，有48名（36%）在治疗前细菌培养呈阳性。除3天治疗组有1例患者外，所有这些患者均实现了细菌学治愈。匹美西林耐受性良好，3天治疗组有7名（7%）患者报告有副作用，7天治疗组有12名（13%）患者报告有副作用。3天治疗组有1名患者、7天治疗组有2名患者因副作用提前停止治疗。
