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乳房切除术和迷走神经切断术对大鼠梳理行为的影响:催乳素的可能作用

Effects of mastectomy and vagotomy on grooming behavior of the rat: possible involvement of prolactin.

作者信息

Gerendai I, Drago F, Continella G, Scapagnini U

出版信息

Physiol Behav. 1984 Jul;33(1):1-4. doi: 10.1016/0031-9384(84)90004-0.

DOI:10.1016/0031-9384(84)90004-0
PMID:6505045
Abstract

Surgical interventions such as unilateral mastectomy or vagotomy affect plasma prolactin (PRL) levels. Right-side mastectomized rats exhibiting high levels of plasma PRL showed increased grooming behavior. Left-side mastectomized rats with low levels of plasma PRL performed poor grooming activity. Bilateral mastectomy that caused a slight increase in plasma PRL levels was followed by enhanced grooming behavior. Both left and right vagotomy resulted in a significant increase in plasma PRL levels. However, only left-side vagotomized rats exhibited increased levels of grooming behavior, while no difference between right-side vagotomized rats and controls occurred. It is possible that changes in plasma PRL levels induced by surgical interventions affect grooming activity of the rat. However, the hypothesis that the integrity of peripheral organs is important for the display of grooming behavior cannot be ruled out.

摘要

单侧乳房切除术或迷走神经切断术等外科手术会影响血浆催乳素(PRL)水平。右侧乳房切除的大鼠血浆PRL水平较高,其修饰行为增加。左侧乳房切除且血浆PRL水平较低的大鼠修饰活动较差。双侧乳房切除术使血浆PRL水平略有升高,随后修饰行为增强。左右两侧迷走神经切断术均导致血浆PRL水平显著升高。然而,只有左侧迷走神经切断的大鼠修饰行为水平增加,而右侧迷走神经切断的大鼠与对照组之间没有差异。手术干预引起的血浆PRL水平变化可能会影响大鼠的修饰活动。然而,外周器官的完整性对修饰行为的表现很重要这一假设不能排除。

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