Hatton D C, Foutz S R, Fitzgerald R D
Physiol Behav. 1984 Jul;33(1):31-5. doi: 10.1016/0031-9384(84)90009-x.
A group (N = 8) of restrained, baroreceptor denervated rats and a sham-operated-control group (n = 8) received discriminated classical conditioning consisting of 30 reinforced trials in which a CS+ was paired with an electric shock US and 30 non-reinforced trials in which a different CS (CS-) was presented alone. The control group displayed a decelerative heart rate CR and a biphasic pressor-depressor blood pressure CR. The denervated group failed to show a heart rate CR but did show a pressor-only blood pressure CR. The URs of the denervated group consisted of a major depressor change in blood pressure and a slight tachycardia whereas the URs of the control group consisted of a slight pressor response and tachycardia. The results indicated that centrally initiated activity in the efferent vagal pathways mediating the decelerative HR CR in rats may be blocked by the absence of normal afferent baroreceptor neural discharge. An integrating role of baroreceptor input was also suggested for the URs.
一组（N = 8）经压力感受器去神经支配的束缚大鼠和一组假手术对照组（n = 8）接受了辨别性经典条件反射，包括30次强化试验，其中条件刺激（CS+）与电击非条件刺激（US）配对，以及30次非强化试验，其中单独呈现不同的条件刺激（CS-）。对照组表现出心率减速条件反应（CR）和双相升压-降压血压条件反应。去神经支配组未能表现出心率条件反应，但确实表现出仅升压的血压条件反应。去神经支配组的非条件反应（URs）包括血压的主要降压变化和轻微的心动过速，而对照组的非条件反应包括轻微的升压反应和心动过速。结果表明，介导大鼠心率减速条件反应的传出迷走神经通路中的中枢启动活动可能因缺乏正常的传入压力感受器神经放电而受阻。压力感受器输入对非条件反应也具有整合作用。
