Dworkin B R, Dworkin S
Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA.
Behav Neurosci. 1995 Dec;109(6):1119-36. doi: 10.1037//0735-7044.109.6.1119.
The baroreflex can be classically conditioned. In neuromuscular blocked (NMB) rats, electrical stimulation of the aortic depressor nerve (ADN) and dopamine-produced blood pressure rise were effective unconditioned stimuli (UCS) for auditory discriminative classical conditioning. The conditioned response (CR) pattern (bradycardia, vasodilatation, and hypotension > 10 torr) closely resembled that of the unconditioned baroreflex. Conditioned stimulus (CS) specificity was demonstrated by discrimination of baroreflex-associated and nonassociated auditory stimuli, and also by elaborating depressor and pressor CRs to auditory CSs, which respectively had been associated with either baro-afferent (depressor) or tail-shock (pressor) UCSs. The conditioned-baroreflex-magnitude increased with trials. These findings support quantitative models in which CRs interact with and calibrate the gain and dynamic properties of natural reflexes.
压力反射可以被经典条件化。在神经肌肉阻滞（NMB）大鼠中，电刺激主动脉减压神经（ADN）以及多巴胺引起的血压升高是听觉辨别性经典条件化的有效非条件刺激（UCS）。条件反应（CR）模式（心动过缓、血管舒张和低血压>10托）与非条件压力反射的模式非常相似。通过区分与压力反射相关和不相关的听觉刺激，以及通过对分别与压力感受器传入（降压）或尾部电击（升压）UCS相关联的听觉CS产生降压和升压CR，证明了条件刺激（CS）的特异性。条件压力反射幅度随试验次数增加。这些发现支持定量模型，其中CR与自然反射的增益和动态特性相互作用并对其进行校准。
