Mistlberger R E, Rechtschaffen A
Physiol Behav. 1984 Aug;33(2):227-35. doi: 10.1016/0031-9384(84)90104-5.
Entrainment of circadian activity rhythms to a fixed daily mealtime was measured in intact and ventromedial hypothalamic (VMH) lesioned rats housed in tilt-cages. Intact rats showed a clear increase in activity for 2-3 hr prior to the 2 hr daytime feeding period. Anticipatory activity in lesioned rats was attenuated or absent during restricted feeding 5-9 weeks after surgery, but was evident in all rats, even those bearing apparently total VMH damage, during a second restricted feeding schedule 14-21 weeks after surgery. These results show recovery of function and argue against a necessary role for the VMH in food entrained rhythms.
在倾斜笼中饲养的完整大鼠和腹内侧下丘脑（VMH）损伤大鼠中，测量了昼夜活动节律与固定每日进餐时间的同步情况。完整大鼠在2小时白天进食期前2 - 3小时活动明显增加。在手术后5 - 9周的限食期间，损伤大鼠的预期活动减弱或消失，但在手术后14 - 21周的第二个限食方案期间，所有大鼠（即使是那些VMH明显完全受损的大鼠）的预期活动都很明显。这些结果显示了功能的恢复，并反驳了VMH在食物诱导节律中起必要作用的观点。
