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[小剂量电离辐射的特征性细胞遗传学效应]

[Characteristic cytogenetic effects of small doses of ionizing radiation].

作者信息

Zavitaeva T A, Sevan'kaev A V, Palyga G F

出版信息

Radiobiologiia. 1984 Sep-Oct;24(5):711-4.

PMID:6505167
Abstract

A study was made of the frequency of chromosome aberrations in human lymphocyte culture after gamma-irradiation (60Co) with doses ranging from 0.05 to 1.0 Gy at dose--rates of 0,005, 0.05 and 0.5 Gy/min. The frequency of structural changes in chromosomes at low doses was higher than it was expected in the case of extrapolating the effect produced by high to low doses of radiation; within the dose range from 0.1 to 0.5 Gy a plateau was registered for aberrations of the exchange type (dicentrics and rings). The abnormal character of the dose dependence of the yield of chromosome aberrations persisted with all three dose - rates under study.

摘要

对人类淋巴细胞培养物在γ射线(60Co)照射后的染色体畸变频率进行了研究,照射剂量范围为0.05至1.0 Gy,剂量率分别为0.005、0.05和0.5 Gy/分钟。低剂量时染色体结构变化的频率高于将高剂量辐射产生的效应外推至低剂量时预期的频率;在0.1至0.5 Gy的剂量范围内,观察到交换型畸变(双着丝粒和环状染色体)出现平稳期。在所研究的三种剂量率下,染色体畸变产额的剂量依赖性均表现出异常特征。

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