Doy T G, Hughes D L
Res Vet Sci. 1984 Sep;37(2):219-22.
Immature Fasciola hepatica were successfully recovered from the body cavity of cattle from two to 21 days after oral infection. Flukes had penetrated the liver in large numbers by day 7 but there did not appear to be a corresponding reduction in the numbers recovered from the body cavity. Liver pathology showed a typical progressive tissue disruption with a neutrophil and lymphocyte infiltration by day 7 and a marked eosinophil response from day 14. The mesothelium of the liver capsule underwent metaplasia, becoming ultimately highly active and columnar.
在口服感染后2至21天，从牛的体腔中成功回收未成熟的肝片吸虫。到第7天时，大量吸虫已侵入肝脏，但从体腔中回收的吸虫数量似乎没有相应减少。肝脏病理学显示，到第7天时出现典型的进行性组织破坏，伴有中性粒细胞和淋巴细胞浸润，从第14天起出现明显的嗜酸性粒细胞反应。肝包膜的间皮发生化生，最终变得高度活跃并呈柱状。
