Presidente P J, McCraw B M, Lumsden J H
Can J Comp Med. 1974 Jul;38(3):271-9.
Three white-tailed deer (Odocoileus virginianus) were inoculated with 1000 metacercariae of Fasciola hepatica and examined on days 7, 14, and 28 postinoculation to determine the early response of a resistant host to this infection. It was concluded that only small numbers of the metacercariae penetrated the intestinal wall into the peritoneal cavity. Flukes that migrated to the liver penetrated through Glisson's capsule, primarily on the parietal surface. Marked fibroplasia and cellular infiltration of the capsule were induced and flukes were killed and destroyed in granulomas immediately beneath the capsule. Migration in hepatic parenchyma was minimal and immature flukes or migratory tracks were not found. There were infiltrations of eosinophils and mononuclear cells, bile duct hyperplasia and fibroplasia in portal areas. A few flukes penetrated through the diaphragm within 14 days postinoculation and on day 28 granulomas were observed on the dorsal surface of the lung where F. hepatica had penetrated this organ. The early reaction of Glisson's capsule to F. hepatica infection in white-tailed deer has not been described in cattle, sheep or swine infected with this fluke.
给三只白尾鹿（弗吉尼亚鹿）接种1000条肝片吸虫的后尾蚴，并在接种后第7天、14天和28天进行检查，以确定抗性宿主对这种感染的早期反应。得出的结论是，只有少量后尾蚴穿透肠壁进入腹腔。迁移到肝脏的吸虫主要通过肝包膜（主要在脏面）穿透。诱导了包膜明显的纤维增生和细胞浸润，吸虫在包膜下方紧邻处的肉芽肿中被杀死和破坏。在肝实质中的迁移极少，未发现未成熟的吸虫或迁移轨迹。门管区有嗜酸性粒细胞和单核细胞浸润、胆管增生和纤维增生。接种后14天内，少数吸虫穿透膈肌，在接种后第28天，在肝片吸虫穿透的肺脏背表面观察到肉芽肿。牛、羊或猪感染这种吸虫后，尚未描述白尾鹿肝包膜对肝片吸虫感染的早期反应。
