Debussche-Depriester C, Mizon J P, Rosa A
Rev Neurol (Paris). 1984;140(11):665-8.
Two cases of rubella with neurological complications are reported. In one case an extensive atypical polyradiculoneuritis was associated with a late albumino-cytologic dissociation. The other presented as a transverse myelitis with meningitis and radiculitis. In neither case was an history of contagion or recent vaccination elicited, and no eruption appeared in either patient. Clinical onset was sudden, with an acute meningitis followed several days later by neurological deficits. The course was marked by successive phases of early rapid deterioration, stabilization and slow regression over several months. Sequelae were minimal. Diagnosis was based on a sharp fall in the ratio of serum/CSF levels of specific antibodies to the rubeola virus. This was sure evidence of the presence of intrathecal synthesis of specific antibodies.
报告了两例伴有神经系统并发症的风疹病例。一例为广泛的非典型多发性神经根神经炎，并伴有迟发性蛋白细胞分离。另一例表现为横贯性脊髓炎合并脑膜炎和神经根炎。两例均未引出传染史或近期接种疫苗史，且两名患者均未出现皮疹。临床起病突然，先是急性脑膜炎，几天后出现神经功能缺损。病程特点是在数月内依次经历早期快速恶化、稳定和缓慢恢复阶段。后遗症轻微。诊断依据是血清/脑脊液中针对风疹病毒的特异性抗体水平比值急剧下降。这是鞘内特异性抗体合成存在的确切证据。
