Cappel R, Van Beers D, Clinet G
Nouv Presse Med. 1980 Feb 9;9(7):433-6.
Examination of the CSF of 107 patients suffering from a viral infection of the central nervous system for the presence of antiviral antibodies indicated that 26 subjects (24 %) developed monospecific antibodies. The distribution of these antibodies differed according to whether the diagnosis was of meningitis or of encephalitis and myelitis since 3 patients out of 73 (4 %) with meningitis developed antibodies whilst the latter were detectable in 23 of the 34 subjects with encephalitis or myelitis (67 %). This difference was highly significant (p 0,001) and suggests that examination for antiviral antibodies in the CSF could be of use in the differential diagnosis between meningitis and encephalitis. Furthermore, the results presented suggest the existence of local production of antiviral antibodies in the CSF.
对107例患有中枢神经系统病毒感染的患者的脑脊液进行抗病毒抗体检测，结果表明26名受试者（24%）产生了单特异性抗体。这些抗体的分布因诊断为脑膜炎还是脑炎及脊髓炎而有所不同，因为73例脑膜炎患者中有3例（4%）产生了抗体，而在34例脑炎或脊髓炎患者中有23例（67%）可检测到抗体。这种差异具有高度显著性（p<0.001），提示脑脊液中抗病毒抗体检测可能有助于脑膜炎和脑炎的鉴别诊断。此外，所呈现的结果表明脑脊液中存在抗病毒抗体的局部产生。
