Kitt C A, Price D L, Struble R G, Cork L C, Wainer B H, Becher M W, Mobley W C
Science. 1984 Dec 21;226(4681):1443-5. doi: 10.1126/science.6505701.
In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course. In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence). The appearance of these amyloid-associated abnormal cholinergic processes was similar to that of neurites in senile plaques, as shown by conventional silver impregnation techniques. Cholinergic systems thus give rise to some of the neurites within senile plaques.
在幼年和老年猕猴的新皮质和杏仁核中，通过抗牛胆碱乙酰转移酶单克隆抗体鉴定出胆碱能轴突。在这些动物中可见许多细小的线性免疫反应性轮廓。在老年动物中，一些胆碱能轴突在其行程中出现多灶性增粗。在某些情况下，具有胆碱乙酰转移酶免疫反应性的神经突与淀粉样蛋白沉积物相关（用硫黄素T荧光显示）。如传统银浸染技术所示，这些与淀粉样蛋白相关的异常胆碱能过程的外观与老年斑中的神经突相似。因此，胆碱能系统产生了老年斑内的一些神经突。
