阿尔茨海默病大脑神经炎性斑块中的胆碱乙酰转移酶免疫反应性

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain.

作者信息

Armstrong D M, Bruce G, Hersh L B, Terry R D

出版信息

Neurosci Lett. 1986 Nov 11;71(2):229-34. doi: 10.1016/0304-3940(86)90564-1.

Abstract

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

摘要

我们使用多克隆抗人胆碱乙酰转移酶（ChAT）抗血清，观察了人类新皮层、杏仁核和海马体中神经炎性斑块淀粉样核心周围的营养不良性ChAT阳性突起。这些数据，以及其他研究者对老年猴子的研究数据，为阿尔茨海默病和阿尔茨海默型老年痴呆症中胆碱能系统的生化异常提供了形态学对应物。