Lumsden A B, McLean A, Lamb D
Thorax. 1984 Nov;39(11):844-9. doi: 10.1136/thx.39.11.844.
The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers.
对人类远端气道上皮的杯状细胞和克拉拉细胞群体进行了检查。通过光学显微镜和电子显微镜对16名吸烟者和4名非吸烟者手术切除标本中的细支气管、终末细支气管和呼吸性细支气管进行了研究。与非吸烟者相比，吸烟者细支气管中的杯状细胞数量显著增加（p<0.001），但在终末/呼吸性细支气管中没有这种差异。相比之下，吸烟者细支气管（p<0.01）以及终末和呼吸性细支气管中的克拉拉细胞数量较低（p<0.01）。这两种细胞频率的改变都可能对吸烟者的小气道功能产生不利影响。
