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Quantitation of platelet membrane glycoproteins in Glanzmann's thrombasthenia and the Bernard-Soulier syndrome by electroimmunoassay.

作者信息

Kristopeit S M, Kunicki T J

出版信息

Thromb Res. 1984 Oct 15;36(2):133-42. doi: 10.1016/0049-3848(84)90335-9.

DOI:10.1016/0049-3848(84)90335-9
PMID:6506033
Abstract

A rapid and precise electroimmunoassay for quantitation of glycoprotein Ib and IIb-IIIa in platelet lysates is described. Using this method, platelets from two patients with Type II thrombasthenia contained 8% and 12% of normal levels of IIb-IIIa, whereas IIb-IIIa was undetectable in platelets of one Type I thrombasthenic patient. The level of Ib in two patients with Bernard-Soulier syndrome was essentially nil. The increased precision of this assay, when compared to CIE, allows for estimations of glycoproteins levels varying by no more than a few percent.

摘要

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