Brattstrom L E, Hardebo J E, Hultberg B L
Stroke. 1984 Nov-Dec;15(6):1012-6. doi: 10.1161/01.str.15.6.1012.
Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. The present study demonstrates a significantly elevated mean plasma MDS concentration in 19 patients with arteriosclerotic cerebrovascular disease compared to 17 controls. Our findings suggest that moderate homocysteinemia might be a risk factor for arteriosclerotic cerebrovascular disease.
在患有甲硫氨酸代谢遗传性异常的受试者的血浆和尿液中，发现以同型半胱氨酸或半胱氨酸-同型半胱氨酸混合二硫键（MDS）形式存在的同型半胱氨酸浓度极高。这些受试者在儿童期发生动脉硬化性血管并发症的发生率很高。同型半胱氨酸会导致内皮细胞损伤和细胞脱离，从而引发动脉硬化的发展。本研究表明，与17名对照组相比，19例动脉硬化性脑血管疾病患者的平均血浆MDS浓度显著升高。我们的研究结果表明，中度高同型半胱氨酸血症可能是动脉硬化性脑血管疾病的一个危险因素。
