Simon T L, Hunt W C, Garry P J
Transfusion. 1984 Nov-Dec;24(6):469-72. doi: 10.1046/j.1537-2995.1984.24685066802.x.
Depletion of body iron stores is a major factor limiting regular blood donations by menstruating females. To determine if regular iron supplementation would solve this problem, we conducted a double-blind study in which menstruating female donors were randomly placed into one of three groups: one taking 39 mg elemental iron, a second taking 39 mg of iron plus 75 mg vitamin C, and a third taking 100 mg vitamin C daily. The women were requested to donate every 8 weeks for at least 1 year. Blood samples were taken on each donation for measurements of hemoglobin, total iron binding capacity (TIBC), and ferritin. In the two groups taking iron supplements hemoglobin and ferritin increased from baseline values and the TIBC decreased. The vitamin C control group showed decreases from baseline for hemoglobin and ferritin and increases in TIBC. Differences between groups taking iron supplements and the group not taking supplements were highly significant. Drop-out from the study was due to various causes; however, iron intolerance was uncommon. Minimal daily iron supplementation was beneficial in maintaining body iron stores and hemoglobin levels in menstruating females on a schedule of blood donation as often as every 8 weeks.
体内铁储备的耗尽是限制经期女性定期献血的一个主要因素。为了确定定期补充铁剂是否能解决这个问题，我们进行了一项双盲研究，将经期女性献血者随机分为三组：一组每天服用39毫克元素铁，另一组每天服用39毫克铁加75毫克维生素C，第三组每天服用100毫克维生素C。要求这些女性每8周献血一次，至少持续1年。每次献血时采集血样，用于检测血红蛋白、总铁结合力（TIBC）和铁蛋白。在服用铁补充剂的两组中，血红蛋白和铁蛋白较基线值升高，TIBC降低。维生素C对照组的血红蛋白和铁蛋白较基线值降低，TIBC升高。服用铁补充剂的组与未服用补充剂的组之间的差异非常显著。研究中的退出是由各种原因导致的；然而，铁不耐受并不常见。对于每8周定期献血一次的经期女性，每日少量补充铁剂有助于维持体内铁储备和血红蛋白水平。
