Milman N, Søndergaard M, Sørensen C M
Blut. 1985 Nov;51(5):337-45. doi: 10.1007/BF00320044.
Iron stores were evaluated by serum ferritin determinations in 948 menstruating and 141 non-menstruating female blood donors. Blood donation was associated with a decrease in ferritin. First-time donors (n = 163) had a geometric mean ferritin of 24 micrograms/l and multiple-time donors a value of 19 micrograms/l (p less than 0.01). In the donating population 31.5% had ferritin values less than 15 micrograms/l (i.e. depleted iron stores). Menstruating donors had lower mean serum ferritin than non-menstruating donors (p less than 0.001), and a higher frequency of ferritin values less than 15 micrograms/l (p less than 0.05). There was no relationship between ferritin levels and the number of pregnancies. The frequency of donations was more predictive of ferritin levels than the number of donations. Mean ferritin displayed a moderate fall up to the 2nd donation, and was hereafter relatively constant, whereas an increase in donation frequency was accompanied by a significant decrease in ferritin. Female donors, especially when phlebotomised greater than or equal to 3 times per year, should have their iron status checked at appropriate intervals by measurement of serum ferritin and should be advised regular iron supplementation.
通过测定血清铁蛋白对948名月经正常的女性献血者和141名非月经女性献血者的铁储备进行了评估。献血与铁蛋白降低有关。首次献血者（n = 163）的铁蛋白几何平均值为24微克/升，多次献血者为19微克/升（p < 0.01）。在献血人群中，31.5%的人铁蛋白值低于15微克/升（即铁储备耗竭）。月经正常的献血者的平均血清铁蛋白低于非月经献血者（p < 0.001），且铁蛋白值低于15微克/升的频率更高（p < 0.05）。铁蛋白水平与怀孕次数之间没有关系。献血频率比献血次数更能预测铁蛋白水平。平均铁蛋白在第二次献血前呈适度下降，此后相对稳定，而献血频率增加伴随着铁蛋白显著下降。女性献血者，尤其是每年采血3次及以上者，应定期通过测定血清铁蛋白检查其铁状态，并应建议其定期补充铁剂。
