Mahajan S K, Abraham J, Migdal S D, Abu-Hamdan D K, McDonald F D
Transplantation. 1984 Dec;38(6):599-602. doi: 10.1097/00007890-198412000-00010.
The effect of successful renal transplantation on zinc metabolism and taste acuity was determined prospectively in 15 adult uremic patients. Before transplantation all patients had subnormal concentrations of zinc in plasma and hair, as well as abnormal taste detection and recognition thresholds for sodium (salty), sucrose (sweet), hydrochloric acid (sour), and urea (bitter). Following renal transplantation, abnormalities of taste acuity and zinc metabolism persisted and were accompanied by increased urinary zinc excretion in all patients. Normalization of zinc concentration in plasma and hair as well as taste acuity did not occur until one year after transplantation and was associated with a concomitant decrease in urinary zinc excretion. The plasma zinc levels and daily urinary zinc excretion were inversely related (r = 0.62, P less than .001) in all patients with normal allograft function. None of the zinc parameters was significantly related to azathioprine or corticosteroid dosage. The results of this study suggest that zinc deficiency and taste abnormalities of uremia persist up to one year posttransplant and may be related to increased urinary zinc losses. The mechanisms underlying post-transplant hyperzincuria as well as clinical significance of zinc deficiency following transplantation remain to be determined.
前瞻性地测定了15例成年尿毒症患者成功肾移植对锌代谢和味觉敏锐度的影响。移植前，所有患者血浆和头发中的锌浓度均低于正常水平，对钠（咸）、蔗糖（甜）、盐酸（酸）和尿素（苦）的味觉检测和识别阈值也异常。肾移植后，所有患者的味觉敏锐度和锌代谢异常持续存在，并伴有尿锌排泄增加。血浆和头发中的锌浓度以及味觉敏锐度直到移植后一年才恢复正常，且与尿锌排泄量的同时减少有关。在所有移植肾功能正常的患者中，血浆锌水平与每日尿锌排泄量呈负相关（r = 0.62，P < .001）。没有一个锌参数与硫唑嘌呤或皮质类固醇剂量有显著相关性。本研究结果表明，尿毒症患者的锌缺乏和味觉异常在移植后长达一年仍持续存在，可能与尿锌丢失增加有关。移植后高锌尿症的潜在机制以及移植后锌缺乏的临床意义仍有待确定。
