Burge J C, Schemmel R A, Park H S, Greene J A
J Am Diet Assoc. 1984 Oct;84(10):1203-6, 1209.
The malnutrition often associated with progressive renal failure may be related to a progressive deterioration of taste acuity. To determine the relationships between taste acuity, zinc status, and progressive renal failure, 27 subjects were divided into three groups and classified as having mild, moderate, or severe renal failure, with creatinine clearance of 41 to 75, 15 to 40, and 5 to 14 ml/minute, respectively. The subjects were evaluated for recognition taste thresholds for sour and sweet by the Cornsweet method. Serum, urinary, and salivary levels for zinc were determined by atomic absorption techniques. Food diaries were kept for two days; intakes of protein and zinc were calculated from the diaries. There was a significant (p less than .01) inverse relationship between creatinine clearance and recognition taste thresholds for sour and sweet. Serum zinc levels were significantly lower (p less than .01) for subjects with severe renal failure than for subjects with mild renal failure. The subjects who ingested more protein also ingested more zinc.
与进行性肾衰竭常相关的营养不良可能与味觉敏锐度的逐渐恶化有关。为了确定味觉敏锐度、锌状态与进行性肾衰竭之间的关系，将27名受试者分为三组，分别归类为轻度、中度或重度肾衰竭，肌酐清除率分别为41至75、15至40和5至14毫升/分钟。采用康斯威特法评估受试者对酸味和甜味的识别味觉阈值。通过原子吸收技术测定血清、尿液和唾液中的锌水平。记录两天的食物日记；根据日记计算蛋白质和锌的摄入量。肌酐清除率与酸味和甜味的识别味觉阈值之间存在显著的（p小于0.01）负相关。重度肾衰竭受试者的血清锌水平显著低于（p小于0.01）轻度肾衰竭受试者。摄入更多蛋白质的受试者也摄入了更多的锌。
