Kuzhir T D, Goncharova R I, Zolotareva G N
Tsitol Genet. 1984 Sep-Oct;18(5):343-7.
Cytogenetic effect of 1,4-dihydropyridine was studied in different test-systems. The preparation is shown to decrease the level of complete sex-chromosome losses in Drosophila and chromosome aberration frequency in Allium fistulosum seedlings. The preparation does not affect spontaneous mutability of bone marrow cells in mice, high doses of the preparation have no mutagenic potential. Thus, 1,4-dihydropyridine shows antimutagenic activity reducing the chromosome mutation level in sex and somatic cells of eucaryotic organisms. Absence of the effect on mice chromosomes may testify to the specificity of 1,4-dihydropyridine action.
在不同的测试系统中研究了1,4 - 二氢吡啶的细胞遗传学效应。结果表明，该制剂可降低果蝇中完整性染色体丢失的水平以及葱幼苗中的染色体畸变频率。该制剂不影响小鼠骨髓细胞的自发突变率，高剂量时也无诱变潜力。因此，1,4 - 二氢吡啶表现出抗诱变活性，可降低真核生物性细胞和体细胞中的染色体突变水平。对小鼠染色体无影响可能证明了1,4 - 二氢吡啶作用的特异性。
