Surkova N I, Malashenko A M
Genetika. 1975;11(1):66-72.
In bone marrow cells of eleven genotypes of mice strain and sex variations in sensitivity to cytogenetic effect of thio-TEPA were studied. Strains 101/H, C57BL/6 and A/Sn were the more sensitive and F1 (CBAXC57BL/6) and F1 (C3HX101) were the more resistant to induction of chromosome damages. The rate of induced chromosome aberrations was correlated with the level of spontaneous chromosome damages in bone marrow cells (r=+/-0,893+/-0,02). From all strains males were more mutable than females. It is recommended to use C57BL/6 strain of mice male for genetic tests of chemicals by cytogenetic methods in vivo.
研究了11种基因型小鼠品系的骨髓细胞以及性别对硫代磷酸三乙酯细胞遗传学效应敏感性的差异。101/H、C57BL/6和A/Sn品系更为敏感，而F1（CBAXC57BL/6）和F1（C3HX101）对染色体损伤的诱导更具抗性。诱导的染色体畸变率与骨髓细胞中自发染色体损伤水平相关（r = ±0.893 ± 0.02）。在所有品系中，雄性比雌性更易发生突变。建议使用C57BL/6品系的雄性小鼠通过体内细胞遗传学方法进行化学物质的遗传测试。
