Leitch D R, Greenbaum L J, Hallenbeck J M
Undersea Biomed Res. 1984 Sep;11(3):237-48.
In a dog model of cerebral arterial gas embolism we studied the relative merits of several different treatments: air breathing at 2.8, 6, 8, and 10 bar (60, 165, 230, and 300 ft), and oxygen breathing at 2.8 bar. The study was confined to the recovery of cortical evoked potentials (CEP) while at pressure. It was confirmed that this was a very severe model; few dogs achieved full recovery and three failed to show any recovery. Injecting 0.4 ml of air into the right internal carotid artery was seen to be as effective in suppressing function in the left hemisphere as in the right. The level of recovery with compression treatment as a percentage of control was directly related to the level to which CEP was suppressed. No other physiological correlates were found with either the degree of CEP suppression or the degree of recovery. Nor was any improvement observed in the rate or maximum amount of recovery at any time out to 20 min as a result of pressures greater than 2.8 bar. Overall, no treatment surpassed oxygen at 2.8 bar.
在犬脑动脉气体栓塞模型中，我们研究了几种不同治疗方法的相对优点：在2.8、6、8和10巴（60、165、230和300英尺）下呼吸空气，以及在2.8巴下呼吸氧气。该研究仅限于在压力下皮层诱发电位（CEP）的恢复情况。证实这是一个非常严重的模型；很少有犬能完全恢复，三只犬未显示任何恢复。向右侧颈内动脉注入0.4毫升空气被认为在抑制左半球功能方面与抑制右半球功能一样有效。加压治疗后的恢复水平占对照的百分比与CEP被抑制的程度直接相关。未发现与CEP抑制程度或恢复程度相关的其他生理关联。在长达20分钟的任何时间内，也未观察到由于压力大于2.8巴而使恢复速率或最大恢复量有任何改善。总体而言，没有哪种治疗方法超过2.8巴下的氧气治疗。
