Leitch D R, Hallenbeck J M, Greenbaum L J
Aviat Space Environ Med. 1983 Feb;54(2):105-11.
The development of dog electrophysiological models for studying the treatment of cerebral arterial air embolism and spinal cord decompression sickness, required that the effects of the treatment gases on spinal and cortical somatosensory evoked potentials (SEP and CEP) be known. We found an inverse linear relationship between CEP amplitude and air pressure to 230 ft. An asymptote was approached when pressure was increased to 300 ft. This effect was not seen with 20% oxy-helium. The waves representing local cord events were depressed to a lesser extent than were the CEPs. We were able to detect an equilibration time in the EP suppression comparable to estimated inert gas wash-in time for the brain. A small depression of CEPs that did not reach significance was seen with exposure to 2.8 bar of oxygen and continuous exposure for up to 120 min caused no further diminution in amplitude than would be caused by time alone.
为研究脑动脉空气栓塞和脊髓减压病的治疗方法而开发犬类电生理模型，需要了解治疗气体对脊髓和皮质体感诱发电位（SEP和CEP）的影响。我们发现CEP振幅与气压至230英尺之间呈反线性关系。当气压增加到300英尺时接近渐近线。20%氧氦混合气未观察到这种效应。代表局部脊髓事件的波比CEP的抑制程度小。我们能够检测到EP抑制中的平衡时间，该时间与估计的大脑惰性气体洗入时间相当。暴露于2.8巴氧气时，CEP有轻微下降但未达到显著水平，持续暴露长达120分钟，振幅的减小并不比仅由时间引起的减小更多。
