使用β受体阻滞剂和血液灌流治疗急性茶碱中毒。
Use of beta-blockade and hemoperfusion for acute theophylline poisoning.
作者信息
Biberstein M P, Ziegler M G, Ward D M
出版信息
West J Med. 1984 Oct;141(4):485-90.
Abstract
Five adults were treated successfully for severe theophylline poisoning due to intentional overdosage. Clinical features included nausea, tremor, delirium, hypotension and cardiac arrhythmias, metabolic acidosis, hyperglycemia, hypokalemia and hypophosphatemia. No seizures or deaths occurred despite very high serum theophylline concentrations (between 96 and 194 mug per ml). Extreme elevations of plasma catecholamines were documented and are implicated in the toxicity. beta-Blockade with intravenous administration of propranolol hydrochloride was the most effective therapy for theophylline-induced hypotension. All patients were treated with resin hemoperfusion, which resulted in significant clinical improvement and rapid lowering of the serum theophylline level.
摘要
五名成年人因故意过量服用导致严重茶碱中毒，经治疗成功康复。临床特征包括恶心、震颤、谵妄、低血压和心律失常、代谢性酸中毒、高血糖、低钾血症和低磷血症。尽管血清茶碱浓度非常高（每毫升96至194微克），但未发生癫痫发作或死亡。记录到血浆儿茶酚胺极度升高，这与毒性有关。静脉注射盐酸普萘洛尔进行β受体阻滞是治疗茶碱引起的低血压最有效的方法。所有患者均接受树脂血液灌流治疗，临床症状显著改善，血清茶碱水平迅速降低。
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