聚肌苷酸-聚胞苷酸与两性霉素B甲酯对L929细胞的协同细胞毒性。
Synergistic cytotoxicity for L929 cells of polyriboinosinic-polyribocytidylic acid and amphotericin B methyl ester.
作者信息
Borden E C
出版信息
J Natl Cancer Inst. 1978 Jun;60(6):1309-11. doi: 10.1093/jnci/60.6.1309.
PMID:650699
Abstract
A synergistic impairment in cell growth of L929 mouse fibroblasts resulted from treatment with a combination of amphotericin B methyl ester and polyriboinosinic-polyribocytidylic acid. This effect, which may result from the altered membrane permeability induced by polyenes, may augment the therapeutic efficacy of polyribonucleotides as antitumor compounds.
摘要
两性霉素B甲酯与聚肌苷酸-聚胞苷酸联合处理导致L929小鼠成纤维细胞的细胞生长出现协同损伤。这种效应可能是由多烯类诱导的膜通透性改变所致，可能会增强聚核糖核苷酸作为抗肿瘤化合物的治疗效果。
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