Lauer K, Firnhaber W
Acta Neurol Scand. 1984 Oct;70(4):266-73. doi: 10.1111/j.1600-0404.1984.tb00824.x.
In order to discover possible exogenous variables associated with a higher multiple sclerosis risk, the distribution of cases with definite and probable multiple sclerosis ascertained in the course of a micro-epidemiologic study in Southern Hesse was evaluated and compared with some environmental factors. The prevalence in 1980, the prevalence of cases with disease-onset within the region according to locality of onset and the rate of native Southern Hesse patients according to childhood residence all showed a similar geographical distribution, with the highest values in the south-eastern, mountainous part of the region. This district has a lower annual mean temperature, more annual snow-days and a higher annual precipitation compared to the remaining area. A statistical comparison revealed no association with industrial or agricultural activities, with a particular type of land use, with cattle, pig- or horse-breeding, or with sanitary or housing standards. On the other hand, a slight association with the soil type could be demonstrated, with higher rates on loam and clay subsoils when compared to predominantly sandy regions. Whether this finding has any significance or not remains to be clarified.
为了发现与多发性硬化症高风险相关的可能的外源性变量，对在黑森州南部进行的一项微观流行病学研究过程中确诊和疑似多发性硬化症病例的分布情况进行了评估，并与一些环境因素进行了比较。1980年的患病率、根据发病地点划分的该地区内发病病例的患病率以及根据童年居住地划分的黑森州南部本地患者的比例均呈现出相似的地理分布，在该地区东南部山区数值最高。与其余地区相比，该地区年平均气温较低，年降雪天数较多，年降水量较大。统计比较显示，与工业或农业活动、特定类型的土地利用、养牛、养猪或养马，或与卫生或住房标准均无关联。另一方面，可证明与土壤类型存在轻微关联，与以沙地为主的地区相比，壤土和粘土壤土上的发病率更高。这一发现是否具有任何意义仍有待阐明。
