长期接触有机溶剂的男性脑脊液中的血管活性肠肽（VIP）

Vasoactive intestinal polypeptide (VIP) in cerebrospinal fluid from men after long-term exposure to organic solvents.

作者信息

Johansson B B, Ben-Menachem E, Ekberg K, Wikkelsø C, Fahrenkrug J

出版信息

Acta Neurol Scand. 1984 Oct;70(4):317-8. doi: 10.1111/j.1600-0404.1984.tb00830.x.

DOI:10.1111/j.1600-0404.1984.tb00830.x

Abstract

Vasoactive intestinal polypeptide (VIP) is widely distributed within the central nervous system (CNS) and is thought to function as a neurotransmitter. VIP was measured in CSF from 14 men with psycho-organic syndrome occupationally exposed to organic solvents for 7-38 years and in CSF from 8 neurologically healthy male volunteers. The concentration of VIP in the exposed group, 28 +/- 15 (SD) pmol/l, did not significantly differ from that of controls, 38 +/- 14 pmol/l. Thus, determination of VIP in CSF appears to be of little value for detecting effects of long-term solvent exposure.

摘要

血管活性肠肽（VIP）广泛分布于中枢神经系统（CNS）内，被认为起着神经递质的作用。对14名职业性接触有机溶剂达7 - 38年的患有精神器质性综合征的男性的脑脊液以及8名神经系统健康的男性志愿者的脑脊液中的血管活性肠肽进行了测量。暴露组血管活性肠肽的浓度为28±15（标准差）pmol/L，与对照组的38±14 pmol/L相比，差异无统计学意义。因此，测定脑脊液中的血管活性肠肽对于检测长期接触溶剂的影响似乎价值不大。