Kaada B, Hegland O, Oktedalen O, Opstad P K
Gen Pharmacol. 1984;15(6):563-5. doi: 10.1016/0306-3623(84)90218-0.
Low-frequency transcutaneous nerve stimulation (TNS) is known to produce a prolonged and widespread cutaneous vasodilatation. This is associated with a moderate but significant increase of 30-35% in the concentration of the vasoactive intestinal polypeptide (VIP) in the cubital vein plasma. A possible source of this increased plasma VIP following TNS is the central nervous system. This possibility is tested in the present experiment. The concentration of VIP in the cerebrospinal fluid (CSF) was determined by radioimmunoassay in 9 patients with no organic disease of the central nervous system, before and at various intervals (15, 30 and 45 min) after the onset of TNS. No significant change in the VIP level of the cerebrospinal fluid was encountered, although the stimulation evoked rises in finger temperature indicating effectiveness of the stimulation. It is concluded that the stimulation-induced increase in plasma VIP is due to release of VIP outside the brain.
低频经皮神经刺激（TNS）已知会产生持久且广泛的皮肤血管舒张。这与肘静脉血浆中血管活性肠肽（VIP）浓度适度但显著增加30 - 35%有关。TNS后血浆VIP增加的一个可能来源是中枢神经系统。本实验对这一可能性进行了测试。通过放射免疫分析法测定了9例无中枢神经系统器质性疾病患者在TNS开始前及开始后不同时间间隔（15、30和45分钟）脑脊液（CSF）中VIP的浓度。尽管刺激引起手指温度升高表明刺激有效，但脑脊液中VIP水平未出现显著变化。结论是，刺激引起的血浆VIP增加是由于脑外VIP的释放。
