Parentage testing using the serum protein plasminogen (PLG).

Isoelectric focusing of plasminogen (PLG) was tested on a Minnesota population of 2,187 white individuals and 451 paternity cases. A total of six different PLG allotypes were observed PLG1, PLG2, PLG3, PLGB, PLGD and PLGM. Observed gene frequencies predicted a probability P = 0.2 of excluding men who were falsely determined to be parents. The observed frequency of PLG exclusions among all exclusions detected in the study using a test battery of 14-16 genetic markers was similar to the expected value. PLG phenotyping proved to be a very useful genetic marker system in routine parentage testing.