McConnachie P R, McIntyre J A
Am J Reprod Immunol (1980). 1984 Jun;5(4):145-50. doi: 10.1111/j.1600-0897.1984.tb00186.x.
Maternal antipaternal immunity was compared between a group of 12 couples with normal reproductive histories and a group of 13 couples with obstetrical histories of more than one consecutive stillbirth or repeated pregnancy loss subsequent to having had successfully carried to term. Couples were studied for maternal-paternal HLA antigen sharing and for maternal antihusband immunity in tests detecting both complement dependent and independent antibodies as well as in an assay measuring direct cell-mediated cytotoxicity. There was no significant difference in the proportion of HLA antigen sharing between these two groups; however, the women in the pregnancy loss group demonstrated significantly more antipaternal immunity than their normal childbearing counterparts and more than previously described for aborting couples who share HLA antigens. Screening of the cytotoxic sera on a well characterized cell panel failed to reveal alloreactivity patterns consistent with paternal HLA antigen profiles. These data demonstrate that certain women who suffer recurrent pregnancy losses can mount vigorous immune responses to paternal lymphocyte antigens. We propose that the appearance of such lymphocytotoxins represents inappropriate maternal immune responses to fetal extraembryonic antigens that may subsequently result in fetal demise.
在一组有正常生育史的12对夫妇和另一组有连续多次死产或反复妊娠丢失病史（此前曾成功足月分娩）的13对夫妇之间，对母源性抗父方免疫进行了比较。研究了夫妇双方的母-父HLA抗原共享情况，以及在检测补体依赖性和非依赖性抗体的试验中以及在测量直接细胞介导的细胞毒性的测定中母方对丈夫的免疫情况。这两组之间HLA抗原共享比例没有显著差异；然而，流产组的女性表现出比正常生育的女性更强的抗父方免疫，且比先前描述的共享HLA抗原的流产夫妇更强。在一个特征明确的细胞板上对细胞毒性血清进行筛选，未能揭示与父方HLA抗原谱一致的同种异体反应模式。这些数据表明，某些反复流产的女性能够对父方淋巴细胞抗原产生强烈的免疫反应。我们认为，这种淋巴细胞毒素的出现代表了母体对胎儿胚胎外抗原的不适当免疫反应，这可能随后导致胎儿死亡。
