Faulk W P, Coulam C B, McIntyre J A
Methodist Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
Environ Health Perspect. 1987 Oct;74:119-27. doi: 10.1289/ehp.8774119.
The objective of this paper is to consider several categories of biomarkers of human pregnancy. The design of the report is to discuss useful and promising markers and techniques. Research gaps, needs, and priorities are also defined. Useful markers are mixed lymphocyte culture reactions, measures of lymphocytotoxic antibodies, histocompatibility (HLA) typing, and immunohematological evaluations. Promising markers are measures of major basic protein and early pregnancy factor, as well as determinations of trophoblast-lymphocyte cross-reactive (TLX) antigens. Promising techniques are fluorescence-activated cell-sorter analysis of maternal blood for fetal and extraembryonic tissues and immunotherapy with TLX and other antigens to prevent spontaneous abortion. It is concluded that immunology has much to offer the development of biomarkers of human pregnancy.
本文的目的是探讨人类妊娠生物标志物的几个类别。报告的设计旨在讨论有用且有前景的标志物和技术。还明确了研究差距、需求和重点。有用的标志物包括混合淋巴细胞培养反应、淋巴细胞毒性抗体检测、组织相容性（HLA）分型以及免疫血液学评估。有前景的标志物包括主要碱性蛋白和早期妊娠因子检测，以及滋养层 - 淋巴细胞交叉反应（TLX）抗原的测定。有前景的技术包括利用荧光激活细胞分选仪分析母血中的胎儿和胚外组织，以及用TLX和其他抗原进行免疫治疗以预防自然流产。结论是免疫学在人类妊娠生物标志物的开发方面有很大贡献。
