Andrusenko I T, Ved'mina E A, Givental' N I, Pasternak N A, Aleksandrova I K
Antibiotiki. 1984 Oct;29(10):770-5.
The effect of subbacteriostatic concentrations of some antibiotics on variation of the features characterizing the serovar and biovar of the cholera germ was studied on 10 strains of V. cholerae E1 Tor of the Inaba serovar having the typical properties. It was shown that even a single exposure to the subbacteriostatic concentrations of some antibiotics resulted in formations of clones differing from the parental strains by a number of significant features, such as the antigenic structure, phage lysability and enterotoxicity. The new features were inherited in a number of generations on multiplication in culture media and in sensitive animal hosts.
在10株具有典型特性的稻叶型霍乱弧菌E1 Tor菌株上，研究了某些抗生素亚抑菌浓度对霍乱病菌血清型和生物型特征变异的影响。结果表明，即使仅一次接触某些抗生素的亚抑菌浓度，也会导致形成一些克隆，这些克隆在许多重要特征上与亲代菌株不同，如抗原结构、噬菌体可裂解性和肠毒性。这些新特征在培养基中传代培养以及在敏感动物宿主体内繁殖时能遗传多代。
