Ishizuki S, Kanda N, Kaneta S, Fujihira E
Arch Int Pharmacodyn Ther. 1984 Oct;271(2):303-14.
Buffalo rats of a low adjuvant-arthritis responder strain demonstrate a continually increasing swelling in the hind foot inoculated with mycobacterial adjuvant, characterized by extensive panostitis, new bone formation and long-delayed bony calcification. A rapid regression of foot swelling was produced by a three-day course of therapy with indomethacin (1 mg/kg) or with dexamethasone (0.1 mg/kg), but a definite rebound was followed soon after termination of the therapy. This recurrent episode occurred repeatedly in the second and third therapeutic trials with the anti-inflammatory drugs in the same animals. The 5 days treatment with either levamisole (5 mg/kg) or cyclophosphamide (5 mg/kg) prevented further increase in the swelling for a long time period after withdrawal of the drug, and enhanced bone mineralization.
低佐剂性关节炎反应株的水牛大鼠在接种分枝杆菌佐剂的后足出现持续肿胀，其特征为广泛的全骨炎、新骨形成和长期延迟的骨钙化。用吲哚美辛（1毫克/千克）或地塞米松（0.1毫克/千克）进行为期三天的治疗可使足部肿胀迅速消退，但治疗结束后不久就会出现明显的反弹。在同一动物的第二次和第三次抗炎药物治疗试验中，这种复发情况反复出现。用左旋咪唑（5毫克/千克）或环磷酰胺（5毫克/千克）进行5天治疗，在停药后的很长一段时间内可防止肿胀进一步加重，并增强骨矿化。
