评估药物对已确诊的II型胶原性关节炎的活性。

Assessment of drugs for activity in established type II collagen arthritis.

作者信息

Jones S A, Kennedy A J, Roberts N A

出版信息

Agents Actions. 1982 Dec;12(5-6):650-6. doi: 10.1007/BF01965074.

DOI:10.1007/BF01965074

Abstract

Arthritis was induced in a proportion of rats sensitized with type II collagen and Freund's incomplete adjuvant. Rats which developed arthritis had significantly higher antibody titres and significantly greater delayed hypersensitivity responses to type II collagen than rats which did not develop arthritis. Anti-inflammatory and anti-rheumatic drugs were evaluated against type II collagen arthritis. Dexamethasone reduced inflammatory swelling, reduced both the antibody titre and delayed hypersensitivity to type II collagen and exerted joint protection. Indomethacin reduced inflammatory swelling. Azathioprine, Clozic, Levamisole, D-Penicilamine and Sulphapyridine did not exert significant beneficial activity in this test.

摘要

在一部分用Ⅱ型胶原和弗氏不完全佐剂致敏的大鼠中诱发了关节炎。发生关节炎的大鼠比未发生关节炎的大鼠具有显著更高的抗体滴度以及对Ⅱ型胶原显著更强的迟发型超敏反应。对Ⅱ型胶原性关节炎评估了抗炎和抗风湿药物。地塞米松减轻了炎症肿胀，降低了抗体滴度以及对Ⅱ型胶原的迟发型超敏反应，并发挥了关节保护作用。吲哚美辛减轻了炎症肿胀。硫唑嘌呤、氯氮平、左旋咪唑、青霉胺和柳氮磺胺吡啶在该试验中未发挥显著的有益作用。