de Toledo-Morrell L, Morrell F, Fleming S, Cohen M M
Behav Neural Biol. 1984 Sep;42(1):1-8. doi: 10.1016/s0163-1047(84)90364-9.
Pentoxifylline, a phosphodiesterase inhibitor, produces a marked reversal of an age-dependent spatial memory deficit in Fischer 344 strain male rats. Performance of 26-month-old animals treated chronically with pentoxifylline approached that of 3-month-old controls. The effect was not dependent upon concurrent administration of the acetylcholine precursor choline chloride. It is concluded that the pentoxifylline-induced reversal of the age-dependent memory decline is not dependent on any presumed facilitation of acetylation and utilization of exogenously supplied transmitter substrate.
己酮可可碱，一种磷酸二酯酶抑制剂，可显著逆转Fischer 344品系雄性大鼠中与年龄相关的空间记忆缺陷。长期接受己酮可可碱治疗的26个月大动物的表现接近3个月大对照组的表现。该效应不依赖于同时给予乙酰胆碱前体氯化胆碱。得出的结论是，己酮可可碱诱导的与年龄相关的记忆衰退逆转不依赖于对外源性供应的递质底物的乙酰化和利用的任何假定促进作用。
