Mogenson G J, Nielsen M
Behav Neural Biol. 1984 Sep;42(1):38-51. doi: 10.1016/s0163-1047(84)90412-6.
Locomotor activity recorded in an automated open-field apparatus was increased substantially by unilateral injections of carbachol, a cholinergic agonist, into the dentate gyrus of the hippocampus. Hyperactivity elicited in this way was reduced significantly when glutamate antagonists were injected into the ipsilateral nucleus accumbens. Injecting gamma-aminobutyric acid into the ipsilateral subpallidal region also reduced the hyperactivity from injections of carbachol into the dentate gyrus. When these compounds were injected into the contralateral accumbens and subpallidal region, respectively, there was little or no reduction in the carbachol-elicited locomotor activity. These observations suggest that neural pathways fom hippocampus to accumbens to subpallidal region may contribute to locomotor activity.
通过向海马齿状回单侧注射胆碱能激动剂卡巴胆碱，可显著增加在自动旷场装置中记录到的运动活动。当向同侧伏隔核注射谷氨酸拮抗剂时，以这种方式引发的多动显著减少。向同侧苍白球下区域注射γ-氨基丁酸也可减少因向齿状回注射卡巴胆碱而引起的多动。当分别将这些化合物注射到对侧伏隔核和苍白球下区域时，卡巴胆碱引发的运动活动几乎没有或没有减少。这些观察结果表明，从海马到伏隔核再到苍白球下区域的神经通路可能与运动活动有关。
