Patel S, Slater P
Department of Physiology, University of Manchester, United Kingdom.
Behav Neurosci. 1988 Aug;102(4):596-600. doi: 10.1037//0735-7044.102.4.596.
The effects of administration of gamma-aminobutyric acid (GABA) compounds into the ventral pallidum and substantia innominata on the locomotor hyperactivity induced by the dopamine agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) in the nucleus accumbens were investigated in rats. Hyperactivity induced by ADTN was antagonized by the GABA receptor agonists muscimol, isoguvacine, and baclofen. The compounds were equally effective in both subpallidal regions. In contrast, the GABA antagonists picrotoxin and bicuculline injected into subpallidal sites had no effects on accumbens-evoked hyperactivity, although by themselves both antagonists caused a mild and transient locomotor stimulation. It is suggested that GABA receptors in the subpallidal areas are involved in locomotor stimulation elicited from the nucleus accumbens.
研究了向大鼠腹侧苍白球和无名质注射γ-氨基丁酸（GABA）化合物对伏隔核中多巴胺激动剂2-氨基-6,7-二羟基-1,2,3,4-四氢萘（ADTN）诱导的运动性多动的影响。ADTN诱导的多动被GABA受体激动剂蝇蕈醇、异谷氨酰胺和巴氯芬拮抗。这些化合物在两个苍白球下区域同样有效。相比之下，注射到苍白球下部位的GABA拮抗剂印防己毒素和荷包牡丹碱对伏隔核诱发的多动没有影响，尽管这两种拮抗剂本身都会引起轻微且短暂的运动刺激。提示苍白球下区域的GABA受体参与了伏隔核引发的运动刺激。
