Brennan M J, Allen D, Aleman D, Azmitia E C, Quartermain D
Behav Neural Biol. 1984 Sep;42(1):61-72. doi: 10.1016/s0163-1047(84)90436-9.
The effects of age on the habituation of exploratory behavior of 8-month- and 28-month-old male C57BL/NNia mice were examined under three different stimulus complexity conditions. Increases in the degree of stimulus complexity resulted in an attenuation of between-session habituation and an initial disruption of within-session habituation by 8-month-old mice. Although increases in stimulus complexity also resulted in an increase in the overall level of exploration by aged mice, stimulus complexity was not found to have a systematic effect on between- or within-session habituation by aged mice. No between-session habituation was observed in aged mice under any of the stimulus complexity conditions. Further, aged mice exhibited significant within-session increases, rather than decreases, in exploration under each stimulus complexity condition. This disruption of within-session habituation in aged mice was found to persist over four daily test sessions. In view of the specific patterns of exploration by aged mice, the disruption of within-session habituation was attributed to age-related differences in reactivity to the arousal-inducing properties of novel stimuli.
在三种不同的刺激复杂性条件下，研究了年龄对8个月和28个月大的雄性C57BL/NNia小鼠探索行为习惯化的影响。刺激复杂性程度的增加导致8个月大的小鼠在不同实验阶段之间的习惯化减弱，以及在同一实验阶段内习惯化的初始破坏。虽然刺激复杂性的增加也导致老年小鼠探索总体水平的提高，但未发现刺激复杂性对老年小鼠在不同实验阶段之间或同一实验阶段内的习惯化有系统性影响。在任何刺激复杂性条件下，老年小鼠均未观察到不同实验阶段之间的习惯化。此外，在每种刺激复杂性条件下，老年小鼠在同一实验阶段内的探索显著增加，而非减少。发现老年小鼠在同一实验阶段内习惯化的这种破坏在四个每日测试阶段中持续存在。鉴于老年小鼠的特定探索模式，同一实验阶段内习惯化的破坏归因于与年龄相关的对新刺激唤醒诱导特性反应性差异。
