肌醇和三碘甲状腺原氨酸对部分肝切除大鼠肝细胞激素反应性的影响。
Effect of inositol and tri-iodothyronine on the hormonal responsiveness of hepatocytes obtained from partially hepatectomized rats.
作者信息
Huerta-Bahena J, García-Sáinz J A
出版信息
Biochem J. 1984 Nov 1;223(3):925-8. doi: 10.1042/bj2230925.
Abstract
Hepatocytes obtained from animals partially hepatectomized (72 h before the experiment) have a diminished responsiveness to alpha 1-adrenergic amines, vasopressin, angiotensin and glucagon and an increased responsiveness to beta-adrenergic amines. Administration of inositol or tri-iodothyronine to the hepatectomized animals induced a recovery in the hepatocyte responsiveness to the Ca2+-dependent hormones and abolished that to beta-adrenergic amines; the response to glucagon was not improved.
摘要
从部分肝切除的动物（实验前72小时）获得的肝细胞，对α1-肾上腺素能胺、血管加压素、血管紧张素和胰高血糖素的反应性降低，而对β-肾上腺素能胺的反应性增加。给肝切除的动物注射肌醇或三碘甲状腺原氨酸可使肝细胞对钙依赖性激素的反应性恢复，并消除对β-肾上腺素能胺的反应性；对胰高血糖素的反应未得到改善。
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本文引用的文献
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Role of calcium in the hormonal regulation of liver metabolism.钙在肝脏代谢激素调节中的作用。
Biochim Biophys Acta. 1981 Dec 30;639(3-4):243-95. doi: 10.1016/0304-4173(81)90012-4.
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J Biol Chem. 1984 Mar 10;259(5):3077-81.
5
Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II.肌醇给药可恢复肝脏再生过程中形成的肝细胞对α1-肾上腺素能胺、血管加压素和血管紧张素II的敏感性。
Biochim Biophys Acta. 1983 Sep 22;763(2):125-8. doi: 10.1016/0167-4889(83)90035-6.
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Sensitivity of liver cells formed after partial hepatectomy to glucagon, vasopressin and angiotensin II.部分肝切除术后形成的肝细胞对胰高血糖素、血管加压素和血管紧张素II的敏感性。
Biochim Biophys Acta. 1983 Sep 22;763(2):120-4. doi: 10.1016/0167-4889(83)90034-4.
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Roles of alpha 1- and beta-adrenergic receptors in adrenergic responsiveness of liver cells formed after partial hepatectomy.
Biochim Biophys Acta. 1983 Sep 22;763(2):112-9. doi: 10.1016/0167-4889(83)90033-2.
8
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.血管加压素和其他可动员钙离子的激素刺激下大鼠肝细胞中磷脂酰肌醇4-磷酸和磷脂酰肌醇4,5-二磷酸的快速分解。
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