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肌醇给药可恢复肝脏再生过程中形成的肝细胞对α1-肾上腺素能胺、血管加压素和血管紧张素II的敏感性。

Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II.

作者信息

Huerta-Bahena J, García-Saínz J A

出版信息

Biochim Biophys Acta. 1983 Sep 22;763(2):125-8. doi: 10.1016/0167-4889(83)90035-6.

DOI:10.1016/0167-4889(83)90035-6
PMID:6412762
Abstract

Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glycogenolysis, gluconeogenesis and ureogenesis in the newly formed hepatocytes. Furthermore, ionophore A23187 is able to stimulate glycogenolysis in these cells, the mechanism through which inositol produces this effect being unknown. A rôle for phosphatidylinositol is suggested.

摘要

实验前72小时接受部分肝切除的大鼠所获取的肝细胞，对α1 - 肾上腺素能胺、血管加压素、血管紧张素II和离子载体A23187不敏感。然而，如果在手术后24小时和48小时给大鼠施用肌醇，上述激素会刺激新形成的肝细胞中的糖原分解、糖异生和尿素生成。此外，离子载体A23187能够刺激这些细胞中的糖原分解，肌醇产生这种作用的机制尚不清楚。提示磷脂酰肌醇起了作用。

相似文献

1
Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II.肌醇给药可恢复肝脏再生过程中形成的肝细胞对α1-肾上腺素能胺、血管加压素和血管紧张素II的敏感性。
Biochim Biophys Acta. 1983 Sep 22;763(2):125-8. doi: 10.1016/0167-4889(83)90035-6.
2
Sensitivity of liver cells formed after partial hepatectomy to glucagon, vasopressin and angiotensin II.部分肝切除术后形成的肝细胞对胰高血糖素、血管加压素和血管紧张素II的敏感性。
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Hypothyroidism abolishes the glycogenolytic effect of vasopressin, angiotensin II and A23187 but not that of alpha 1-adrenergic amines in rat hepatocytes.
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Effect of inositol and tri-iodothyronine on the hormonal responsiveness of hepatocytes obtained from partially hepatectomized rats.肌醇和三碘甲状腺原氨酸对部分肝切除大鼠肝细胞激素反应性的影响。
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Glycogenolytic effects of the calcium ionophore A23187, but not of vasopressin or angiotensin, in foetal-rat hepatocytes.钙离子载体A23187对胎鼠肝细胞具有糖原分解作用，而血管加压素或血管紧张素则无此作用。
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Effects of adrenergic agents, vasopressin and ionophore A23187, on the phosphorylation of, and flux through, phenylalanine hydroxylase in rat liver cells.肾上腺素能药物、血管加压素和离子载体A23187对大鼠肝细胞中苯丙氨酸羟化酶磷酸化及通量的影响。
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Phorbol esters, vasopressin and angiotensin II block alpha 1-adrenergic action in rat hepatocytes. Possible role of protein kinase C.
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引用本文的文献

1
Switching from alpha 1- to beta-subtypes in adrenergic response during primary culture of adult-rat hepatocytes as affected by the cell-to-cell interaction through plasma membranes.成年大鼠肝细胞原代培养过程中，通过质膜进行细胞间相互作用对肾上腺素能反应中从α1亚型向β亚型转换的影响。
Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):313-21. doi: 10.1042/bj3030313.
2
Effect of inositol and tri-iodothyronine on the hormonal responsiveness of hepatocytes obtained from partially hepatectomized rats.肌醇和三碘甲状腺原氨酸对部分肝切除大鼠肝细胞激素反应性的影响。
Biochem J. 1984 Nov 1;223(3):925-8. doi: 10.1042/bj2230925.
3
Inositol trisphosphate and diacylglycerol as second messengers.肌醇三磷酸和二酰甘油作为第二信使。
Biochem J. 1984 Jun 1;220(2):345-60. doi: 10.1042/bj2200345.

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